Summary of Recommendations for the Prevention and Treatment of Augmentation

WHITE PAPER SUMMARY OF RECOMMENDATIONS FOR THE PREVENTION AND TREATMENT OF RLS/WED AUGMENTATION
A COMBINED TASK FORCE OF THE IRLSSG, EURLSSG AND THE RLS‐FOUNDATION

Click on below link to download the paper.   For permission to reproduce or distribute the paper contact secretary@irlssg.org.

Click here:  Summary of recommendations RLS/WED Augmentation May 2015 (PDF)

Members of the Task Force

Diego Garcia‐Borreguero, MD, Madrid, Spain*
Richard P. Allen, PhD, Baltimore, MD, USA*
Michael H. Silber, MBChB, Rochester, MN, USA*
John W. Winkelman, MD, Boston, MA, USA*
Birgit Högl, MD, Innsbruck, Austria*
Jacquelyn Bainbridge, PharmD, Denver, CO, USA
Mark Buchfuhrer, MD, Downey, CA, USA
Georgios Hadjigeorgiou, MD, Thessaly, Greece
Yuichi Inoue, MD, Tokyo, Japan
Mauro Manconi, MD, Lugano, Switzerland
William Ondo, MD, Houston, TX, USA
Juliane Winkelmann, MD, Stanford, CA, USA
*Member of the writing committee

2015 Science Summit October 22-26, 2015

International RLS Study Group (IRLSSG)and European RLS Study Group (EU-RLSSG) 2015 RLS/WED SCIENCE SUMMIT

OCTOBER 22-26, 2015 held in Asilomar Conference Grounds in Pacific Grove, CA

COMMITTED TO ADVANCING BASIC AND CLINICAL RESEARCH ON RLS/WED

Download the Preliminary Program RLS/WED Science Summit 2015 Program (PDF Flyer)

Registration Rates and Hotel and Food Cost
IRLSSG and EU-RLS Members:  $300
Non-Members $1200
Hotel at Asilomar Conference Grounds (includes breakfast, lunch and dinner)  $240 per night or $120 per day for breakfast, lunch and dinner only.
Registration and hotel reservations can be sent to secretary@irlssg.org.  Priority deadline is July 1, 2015.

REGISTRATION FORM: Registration Form (PDF)

2015 RLS/WED Science Summit Program Committee

Diego Garcia-Borreguero (co-chair)
Juliane Winkelmann (co-chair)

Richard Allen
WH Oertel
Daniel Picchietti
Marco Zucconi

PROGRAM

THURSDAY OCTOBER 22, 2015
Noon – 10:00pm Check-in and registration
6:00pm – 6:20pm Opening reception
6:20pm – 7:00pm BBQ dinner at Crocker Dining Hall
7:30pm – 9:00pm Opening remarks, networking, and social reception

FRIDAY OCTOBER 23, 2015
7:30am – 8:00am Breakfast at Crocker Dining Hall
8:15am – 8:30am Opening session
8:30am – 10:00am Session 1 – Epidemiology
10:00am – 10:20am Coffee Break
10:20am – 11:50am Session 2 – Animal Models for RLS Phenotype
Noon – 1:00pm Lunch at Crocker Dining Hall
1:15pm – 3:15pm Session 3 – Genetics
3:15pm – 3:30pm Coffee Break
3:30pm – 5:00pm Session 4 – Spinal and cortical excitability/hyperarousal
5:00pm – 6:00pm Writing Session and Posters
6:00pm – 7:00pm Break, sunset view at 6:20pm; dinner at Crocker Dining Hall
7:30pm – 8:30pm Debate on Diagnostic Criteria: HB Lee, Dan Picchietti, and Art Walters
8:30pm – 9:30pm Posters, discussion, and social networking

SATURDAY OCTOBER 24, 2015
7:30am – 8:00am Breakfast at Crocker Dining Hall
8:00am – 9:30am Session 5 – PLMS discussion session
9:30am – 9:50am Coffee Break
9:50am – 11:50am Session 6 – The Role of Iron
Noon – 1:00pm Lunch at Crocker Dining Hall
1:15pm – 2:45pm Session 7 – The Dopaminergic System and RLS: Where are We and What Next
2:45pm – 3:00pm Coffee Break
3:00pm – 4:30pm Session 8 – Opioids and pain in RLS
4:30pm – 5:30pm Writing Session and Posters
6:00pm – 7:00pm Break, sunset view at 6:20pm; dinner at Crocker Dining Hall
7:30pm – 8:30pm Genetics of PLMs: E Mignot
8:30pm – 9:30pm Posters, discussion, and social networking

SUNDAY OCTOBER 25, 2015
7:30am – 8:00am Breakfast at Crocker Dining Hall
8:10am – 9:40am Session 9 – RLS and cardiovascular disease: current evidence and a
roadmap for future research*
9:40am – 10:00am Coffee Break
10:00am – 11:30am Session 10 – Brain imaging and connectivity
Noon – 1:00pm Lunch at Crocker Dining Hall
1:15pm – 2:45pm Session 11 – New treatment implications of current science*
2:45pm – 3:00pm Coffee Break
3:00pm – 4:30pm Session 12 – Clinical updates
4:30pm – 6:00pm Writing Session and Posters
6:00pm – 7:00pm Break, sunset view at 6:20pm; dinner at Crocker Dining Hall
7:30pm – 8:30pm Next Generation RLS Researchers – increasing awareness on RLS
Research for Young scientists and clinicians: Wolfgang H Oertel and J Montplaisir
8:30pm – 9:30pm Discussion and next steps
9:30pm – 10:00pm Networking

MONDAY OCTOBER 26, 2015
5:00am – Noon Depart for airports
7:30am – 8:30am Breakfast at Crocker Dining Hall
8:30am – 11:30am Writing sessions

 

SESSION 1 Epidemiology

CO-CHAIRS Daniel Picchietti, Klaus Berger

SPEAKERS AND TITLE
Daniel Picchietti
How has epidemiological research helped the field of WED/RLS?  (brief introduction)
Stephen van den Eeden
Opportunities and limits of secondary data sources in WED/RLS research What needs to be done in WED/RLS epidemiological
Klaus Berger
Convergence of WED/RLS epidemiological research with genetic,biologic, and other areas of WED/RLS research
Daniel Picchietti and Klaus Berger  
Summary

SESSION 2 Animal models for RLS phenotype

CO-CHAIRS Bryon Jones, David Rye

SPEAKERS AND TITLE
Juliane Winkelmann
The role of Meis1, a gene nominated by GWAS, in behaviors mimicking RLS
Yunqing Li
The role of Btbd9, a gene nominated by GWAS, in behaviors and iron regulation related to RLS
Subhabrata Sanyal
Ubiquitination in Drosophila as related to RLS
Richard Allen
BXD 40, a mouse that when fed an iron-poor diet, exhibits endo- and exo-phenotypes mimicking RLS
Byron Jones & David Rye
Discussion

SESSION 3 Genetics

CO-CHAIRS Guy Rouleau, Juliane Winkelmann

SPEAKERS AND TITLE
Juliane Winkelmann
The search for common variants: GWAS studies – an update
Barbara Schormair
The search for rare variants: WES and WGS studies of RLS
Guy Rouleau
Genetic architecture of RLS”, including “common variants” and
“rare variants” and thoughts about “missing heritability.”
David Rye
From genotype to phenotype in RLS and PLMS
Juliane Winkelmann
Summary and discussion

SESSION 4 Spinal and cortical excitability/hyperarousal

CO-CHAIRS Liborio Parrinoco, Walter Paulus

SPEAKERS AND TITLE
Imad Ghorayeb
Spinal physiology in non-human primate models of RLS
(Bordeaux)
Cornelius Bachmann
Physiology of spinal sensory processing in RLS alternatively RLS and its relation to pain at a spinal level
Walter Paulus
Spinal excitability and methods of stimulation
Yuping Wang
Cortical excitability
Giuseppe Lanza
Discussion on spinal and cortical excitability hyperarousal
Walter Paulus & Liborio Parrino
Summary

SESSION 5 PLMS*

CO-CHAIRS Raffaele Ferri, Stephany Fulda

SPEAKERS AND TITLE
Jacques Montplaisir
PLMS as a cardiovascular risk factor: evidence and mechanisms
Stephany Fulda
Evidence-based criteria are needed to score PLMS
Liborio Parrino
Neurophysiological mechanisms of driving PLMS
Raffaele Ferri & Stephany Fulda
Discussion

SESSION 6 The role of iron

CO-CHAIRS James Connor, Richard Allen

SPEAKERS AND TITLE
James Connor
Blood Brain Barrier iron – CSF from RLS patient
Stephanie Patton
Iron – Hypoxia interaction: central and peripheral effects including effects on genes and peripheral myelin
Richard Allen
Pre-clinical and clinical data on effects of iron deficits and iron treatments
Konrad Oexle
Genetic factors of iron
Richard Allen & James Connor
Discussion

SESSION 7 The dopaminergic system and RLS: where are we and what next

CO-CHAIRS Chris Earley, Stephan Clemens

SPEAKERS AND TITLE
Sergi Ferre
DA receptor heteromers as possible new targets for RLS
George Uhl
DAergic systems and cell adhesion molecules. How might they inform us about RLS, augmentation and novel therapeutic targets
Chris Earley
The state of the DAergic system in RLS
Stefan Clemens
The spinal DAergic system and relevance to RLS
Chris Earley & Stephan Clemens
Discussion

SESSION 8 Opioids and pain in RLS

CO-CHAIRS Claudia Trenkwalder, Walter Zieglgänsberger

SPEAKERS AND TITLE
Walter Zieglgänsberger
The interaction of pain physiology and the opioid system:from animals to humans
Birgit Hoegl
The contribution of Sleep and Sleep deprivation for pain
Sam Ahmedzai
Actions of commonly used opioid medications; mechanisms and actions of opioids
Claudia Trenkwalder
Possible mechanisms of action for opioid treatment in RLS – lessons from clinical trials
Claudia Trenkwalder
Discussion; What type of pain is occurring in RLS patients

SESSION 9 RLS and cardiovascular disease: current evidence and a roadmap for future research*

CO-CHAIRS John Winkelman, Virend Somers

SPEAKERS AND TITLE
John Winkelman
Epidemiologic evidence linking RLS and other sleep disorders to cardiovascular disease
Virend Somers
Neural mechanisms linking RLS and other sleep disorders to cardiovascular disease
John Floras
Vascular mechanisms linking RLS and other sleep disorders to cardiovascular disease
Naresh Punjabi
Inflammatory/metabolic mechanisms linking RLS and other sleep disorders to cardiovascular disease
John Winkelman & Virend Somers
Open discussion on how relates to RLS.

SESSION 10 Brain imaging and connectivity

CO-CHAIRS Giovanni Rizzoco, Yong Won Cho

SPEAKERS AND TITLE
Giovanni Rizzo
Brain MRI in RLS. Include both
1) Iron level to possible structural changes
2) Regional brain metabolic dysfunctions in RLS patients: magnetic resonance spectroscopy findings
Maria I. Argyropoulou
Task-evoked functional MRI for studying RLS
Enzo Tagliazucchi
Investigating brain connectivity from resting state functional MRI recordings: methodological aspects
Yong Won Cho
Resting state functional MRI assessments in RLS
Giovanni Rizzo & Young Won Cho
Discussion

SESSION 11 New treatment implications of current science*

CO-CHAIRS Diego Garcia-Borreguero, Sergi Ferre

SPEAKERS AND TITLE
Chris Earley
A possible role of adenosine, histamine, and glutamate in RLS
Diego Garcia Borreguero
Role of drugs acting on the calcium channels
Mauro Manconi
The future of animal models for drug development of RLS; Animal models for rapid screening of RLS
Sergi Ferre
Getting mechanistic with new in vivo models of cortico-striatal neurotransmission
Diego Garcia Borreguero
Summary discussion of future treatments with interactive questions and answers 30

SESSION 12 Clinical updates

CO-CHAIRS Luigi Ferini-Strambi, S Chokroverty

SPEAKERS AND TITLE
Marco Zucconi
Summary review of the PLMS task force
Ferini-Strambi & Chokroverty
Discussion of PLMS task force
Mike Silber
Summary review of the treatment algorithm from the augmentation
task force
Ferini-Strambi & Chokroverty
Discussion of treatment algorithm
Bill Ondo
Deep brain stimulation and RLS: Pathophysiology considerations
Ferini-Strambi & Chokroverty
Discussion of DBS and overall summary of clinical updates

 

Contact us for registration, hotel reservations, and sponsorship opportunities:
Administration Office
Attn: Allan O’Bryan
IRLSSG
3270 19th ST NW I Suite 110
Rochester, MN 55901 USA
email: secretary@irlssg.org
website: www.irlssg.org

Download the Preliminary Program RLS/WED Science Summit 2015 Program (PDF Flyer)

Collaborative Online Valencia-Based Educational Program

Derived from the IRLSSG 2013 Annual Meeting and the 2013 World Congress on Sleep Medicine held in Valencia, Spain, this online program will incorporate recorded lectures, interviews, supportive slides, and videotapes, to provide updates and summaries on current RLS research and the clinical environment.

Click on the image below to access the online educational program.

for irlssg site

 

Long-term treatment guidelines of RLS published in Sleep Medicine (2013)

2016 Annual Meeting

International RLS Study Group Annual Meeting 2016

Location: Denver CO at APSS Sleep 2016

Place: To be determined

Date: Saturday June 11, 2016

More information will be available later in the 2015 year.

Summary of Recommendations for the Long-Term Treatment of RLS/WED from an IRLSSG Task Force

Summary of Recommendations for the Long-Term Treatment of RLS/WED from an IRLSSG Task Force

Click on the link below to read online or download.

Summary-of-RLS-Treatment-Recommendations.pdf