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2018 Annual Meeting

International RLS Study Group Annual Meeting 2018

Location: University of Maryland, SMC Campus Center, 621 W Lombard St, Baltimore MD

Room: Multipurpose Room 349 (Map Below)

Date: Saturday June 2, 2018

Time: 9:00am – 6:00pm


International RLS Study Group


Denise Sharon, Garima Shukla, Aaro Salminen


Aaro Salminen

9:00 am  -  9:10 am    Welcome to Baltimore -  Chris Earley

9:10 am  -  9:30 am     RLS: a hypoadenosinergic state - S. Ferre

9:30 am  -  9:50 am     Changes in responsiveness to dopaminergics over time: impact of long-term treatment and aging - S. Clemens

9:50 am  - 10:10 am    Pathophysiology of RLS: what can we learn from genetics? - A. Salminen

10:10 am - 10:30 am   Year in Review, Projects and Future directions - Diego Garcia-Borreguero

10:30 am - 11:00 am  Coffee break

Moderator:  WHA Review Committee Chair

11:00 am -  12:30 pm  WHA presentations, including or following: Identification of Novel Candidate Biomarkers for RLS by Proteomic Analysis - Stefania Mondello

12:30 am - 1:30 pm   Lunch

Moderator: Denise Sharon

1:30  pm - 1:40 pm     Optimal diagnostic methods for epidemiologic studies and clinical trials - Richard Allen

1:40 pm - 1:50 pm     Predictors of treatment effects and treatment trajectories in clinical trials.

  1. Fulda

2:00 pm - 2:20 pm      Opioid Registry - John Winkelman

2:20 pm - 2:40 pm      Animal models proposal - M. Manconi

2:40 pm - 3:00 pm      sIRLS Validation study - Denise

3:00 pm -3:20 pm       Coffee break

3;20 pm - 3:40 pm     Periodic and non-periodic leg movements during sleep in children and adolescents with RLS or Narcolepsy Raffaele Ferri

3:40 pm - 4:00 pm     Restless sleep vs Restless Legs Syndrome in children: a diagnostic challenge - Lourdes DelRosso

4:00 pm - 4:30 pm     Update on treatment:

Inoue - DA augmentation and alpha-2-delta

  1. Earley- Iron guidelines
  2. Silber - Opiates guidelines

4:30 pm - 4:40 pm     The Stroke - RLS relationship: case discussion - Anupama Gupta

4:40 pm - 5:00 pm   Networking

5:00 pm - 6:00 pm  Business meeting


IRLSSG Accepted as Society Member of World Sleep Society

In 2016, World Sleep Federation (WSF) and World Association of Sleep Medicine (WASM) collaborated to found one international organization: World Sleep Society. As of 2017, IRLSSG is an Associate Society Member of World Sleep Society.

The goal and purpose of the World Sleep Society is to advance knowledge about sleep, circadian rhythms, sleep health, and sleep disorders worldwide, especially in those parts of the world where this knowledge has not advanced sufficiently. This endeavor will promote clinical and scientific information for scientists, health care personnel, and the general public.


2017 Annual Meeting

International RLS Study Group Annual Meeting 2017

Location: Prague during World Sleep 2017

Date: Saturday, October 7, 2017

Time: 08:00 – 17:30

Prague Congress Centre (Kongresové centrum Praha)
5. kvetna 65
140 21 Prague 4, Czech Republic
630 80 249

Room: CLUB H

Course, Club H
07.10.2017, 08:00 – 17:30
Course 100: International RLS Study Group: RLS is not just leg kicking

D. Garcia-Borreguero, Spain

This year's educational program will introduce new and expanded data on RLS and limb movements. Several presentations will discuss the association of weight and RLS with and without PLMS. Recent data from imaging studies contribute to the understanding of the pathophysiology of RLS. More presentations will debate the unequivocal association of sleep related limb movements and RLS. Clinical aspects of RLS in adults and children will be reviewed. Finally, treatment conundrums will be discussed. New this year, we will present opportunities for international collaboration.

Welcome to IRLSSG in Prague
K. Sonka, Czech Republic
08:00 – 08:10

Obesity and RLS
X. Gao, United States
08:10 – 08:30

RLS severity and BMI
F. Provini, Italy
08:30 – 08:50

RLS and BMI in stroke patients
M. Manconi, Switzerland
08:50 – 09:10

Cerebral hemodynamic disturbances in RLS with PLMs
K.Y. Jung, Republic of Korea
09:10 – 09:30

Resting state and thalamic role in RLS
Y.W. Cho, Republic of Korea
09:30 – 09:50

Coffee break - AM
09:50 – 10:20

Sleep related leg movements: Beyond PLM
R. Allen, United States
10:20 – 10:40

Beyond PLMS: The neurophysiology of short-interval leg movements during sleep
R. Ferri, Italy
10:40 – 11:00

Periodic vs. respiratory related leg movements
S. Fulda, Switzerland
11:00 – 11:20

PLMS mimicking RBD
A. Iranzo, Spain
11:20 – 11:40

Wayne Hening Award Abstract presentations

Circadian locomotor activity in Meis1 knock-out mice
A. Salminen, Germany
11:40 – 11:50

Validation of an automatic scoring algorithm for the analysis of periodic limb movements according to the WASM2016 guidelines
D. Alvarez-Estevez, The Netherlands
11:50 – 12:00

Association of BTBD9 and MAP2K5/SKOR1 With Restless Legs Syndrome in Chinese Population
G. Li, China
12:00 – 12:10

Plantar reflex excitability fluctuations in Restless legs syndrome patients
S. Kerr, South Africa
12:10 – 12:20

Prevalence and associated factors of restless legs syndrome and periodic limb movement in EPISONO cohort
L. Kim, Brazil
12:20 – 12:30

Lunch break
12:30 – 13:30

Actigraphy and PLMS
D. Kemlink, Czech Republic
13:30 – 13:50

Ped RLS TF report
A. Walters, United States
13:50 – 14:10

Opiates vs. alpha 2 delta in RLS
D. Garcia-Borreguero, Spain
F. Sixel-Döring, Germany
14:10 – 15:10

Coffee break - PM
15:10 – 15:40

International Projects – our experience
J. Winkelmann, Germany
A. Walters, United States
15:40 – 15:50

International Projects – Networking for Science Group Session
D. Garcia-Borreguero, Spain
15:50 – 16:30

IRLSSG Business Meeting
D. Garcia-Borreguero, Spain
16:30 – 17:30

Guidelines for First-line Treatment of RLS, Prevention and Treatment of Augmentation


Title:  Guidelines for the first-line treatment of restless legs syndrome/Willis–Ekbom disease, prevention and treatment of dopaminergic augmentation: a combined task force of the IRLSSG, EURLSSG, and the RLS-Foundation
ISSN: 1389-9457
DOI: 10.1016/j.sleep.2016.01.017



Click on below link to download the paper.   For permission to reproduce or distribute the paper contact

Click here: Summary of recommendations RLS Augmentation 13Aug2015 (PDF)
(updated on August 13, 2015 with corrected serum ferritin level)

Members of the Task Force

Diego Garcia‐Borreguero, MD, Madrid, Spain*
Richard P. Allen, PhD, Baltimore, MD, USA*
Michael H. Silber, MBChB, Rochester, MN, USA*
John W. Winkelman, MD, Boston, MA, USA*
Birgit Högl, MD, Innsbruck, Austria*
Jacquelyn Bainbridge, PharmD, Denver, CO, USA
Mark Buchfuhrer, MD, Downey, CA, USA
Georgios Hadjigeorgiou, MD, Thessaly, Greece
Yuichi Inoue, MD, Tokyo, Japan
Mauro Manconi, MD, Lugano, Switzerland
William Ondo, MD, Houston, TX, USA
Juliane Winkelmann, MD, Stanford, CA, USA
*Member of the writing committee

2016 Annual Meeting

International RLS Study Group Annual Meeting 2016

Location: Denver during APSS SLEEP 2016

Date: Sunday, June 12, 2016

Time: 8:00 AM – 8:30 PM

Place: Denver Athletic Club
             1325 Glenarm Pl
             Denver, CO 80204
             Phone:   303-534-1211

Walking Directions from SLEEP:  Exit convention center on 14th ST.  Take right (south-east) one block on 14TH ST.  Located on corner of Glenarm and 14th ST.

Room: Centennial Room

RSVP at:

PDF: IRLSSG Symposium Denver 2016 agenda and directions

Presentations on RLS

RLS and iron

08:00-08:20 AM        Effects of iron deficits and iron treatments

                                         Richard Allen            

08:20-08:40 AM       The genetics of iron regulation and its importance for RLS

                                         Byron Jones


 08:40-09:00 AM       From genotype to phenotype in RLS and PLMS

                                         David Rye

09:00-09:30 AM       Dopaminergic systems and cells adhesion molecules: Novel therapeutic targets

                                        George Uhl

 09:30-10:00 AM       Coffee break

 Treatment implications

 10:00-10:20 AM       Quality measures of RLS care

                                         Denise Sharon

10:20-10:40 AM       Role of drugs acting on calcium channels

                                        Diego Garcia-Borreguero

10:40-11:00 AM       Treatment algorithm from the augmentation task force

                                       Mike Silber

11:00-11:20 AM       RLS and Hypoxia

                                       Ambra Stefani

11:20-11:40 AM       Quantitative Sensory Test for RLS

                                      Yong Won Cho        

11:40-12:00              Withdrawal symptoms from dopaminergic compared to non-dopaminergic RLS treatment

                                      Richard Allen

12:00-12:20 PM       Vitamin D deficiency and treatment in Sicilian ambulatory RLS patients

                                      Rosalia Silvestri

12:20-01:20 PM       Lunch

01:30-02:30 PM       Young Investigator award recipients

 RLS and cardiovascular disease

02:30-03:00 PM        Epidemiology linking RLS and CVD

                                         John Winkelman

 Current controversies

03:00-03:30 PM       RLS Augmentation under opioids vs Opioid induced hyperalgesia

Sudhansu Chokroverty and Diego Garcia-Borreguero

 3:30-4:00 PM           Coffee break

 Business Meeting

4:00-5:30 PM           Business Meeting


 5:30-6:00 PM           Networking, social, and drinks

6:00-8:00 PM           Dinner    (Denver Athletic Club – Denver Room 1)

8:00-8:30 PM           Award recognition and social networking

 Please RSVP (not required but appreciated to confirm lunch and dinner numbers):

2012 Consensus IRLSSG Diagnostic Criteria for RLS

2011 Revised IRLSSG Diagnostic Criteria for RLS

Restless legs syndrome (RLS), a neurological sensorimotor disease often profoundly disturbing sleep and quality of life has variable expression influenced by genetic, environmental and medical factors. The symptoms vary considerably in frequency from less than once a month or year to daily and severity from mildly annoying to disabling. Symptoms may also remit for various periods of time. RLS is diagnosed by ascertaining symptom patterns that meet the following five essential criteria adding clinical specifiers where appropriate.


Essential Diagnostic Criteria (all must be met)

1. An urge to move the legs usually but not always accompanied by or felt to be caused by uncomfortable and unpleasant sensations in the legs.1, 2

2. The urge to move the legs and any accompanying unpleasant sensations begin or worsen during periods of rest or inactivity such as lying down or sitting.

3. The urge to move the legs and any accompanying unpleasant sensations are partially or totally relieved by movement, such as walking or stretching, at least as long as the activity continues. 3

4. The urge to move the legs and any accompanying unpleasant sensations during rest or inactivity only occur or are worse in the evening or night than during the day.4

5. The occurrence of the above features are not solely accounted for as symptoms primary to another medical or a behavioral condition (e.g., myalgia, venous stasis, leg edema, arthritis, leg cramps, positional discomfort, habitual foot tapping.) 5


Specifiers for Clinical Course of RLS6

A. Chronic-persistent RLS: Symptoms when not treated would occur on average at least twice weekly for the past year.

B. Intermittent RLS: symptoms when not treated would occur on average < 2/week for the past year, with at least 5 lifetime events.

Specifier for Clinical Significance of RLS6

The symptoms of RLS cause significant distress or impairment in social, occupational, educational or other important areas of functioning by the impact on sleep, energy/vitality, daily activities, behavior, cognition or mood.



1. Sometimes the urge to move the legs is present without the uncomfortable sensations and sometimes the arms or other parts of the body are involved in addition to the legs.

2. For children, the description of these symptoms should be in the child's own words.

3. When symptoms are very severe, relief by activity may not be noticeable but must have been previously present.

4. When symptoms are very severe, the worsening in the evening or night may not be noticeable but must have been previously present.

5. These conditions, often referred to as “RLS mimics”, have been commonly confused with RLS particularly in surveys because they produce symptoms that meet or at least come very close to meeting criteria 1-4. The list here gives some examples of this that have been noted as particularly significant in epidemiological studies and clinical practice. RLS may also occur with any of these conditions, but the RLS symptoms will then be more in degree, conditions of expression or character than those usually occurring as part of the other condition.

6.The clinical course criteria do not apply for pediatric cases nor for some special cases of provoked RLS such as pregnancy or drug induced RLS where the frequency may be high but limited to duration of the provocative condition.

Wayne Hening Young Investigator Awards

Wayne Hening Young Investigator Awards

Named to honor the memory of a pioneer in RLS research and established in 2010, the Wayne Hening Young Investigator Awards are presented at the annual meeting of the IRLSSG. The $1,000 awards recognize research efforts by new investigators in an attempt to promote interest in the study of RLS.

The Wayne Hening Young Investigator Awards will be made to welcome:

1. Either young investigators new to the RLS/PLMS field who are no more than 10 years past receiving their PhD or MD; or
2. Senior investigators new to the RLS/PLMS field (first publication of a first author abstract or journal article in the RLS/PLMS field is within the last 3 years); and
3. Their scientific RLS/PLMS work was accepted for presentation

The awardees are expected to present their work at the IRLSSG annual meeting.  Abstracts considered for award will be judged based on work quality and relevance to the field.

Award applications should include the following: 1. Name, address, and scientific affiliation 2. Current job and professional role 3. Scientific mentor/senior associate (for junior investigators) 4. Submitted abstract and official indication of acceptance or scientific role of the applicant in the scientific encounter with official documentation attached to the application (this can be submitted later than the initial application if relevant information is unavailable at the first point). 5. Other information supporting the application when appropriate or needed (e.g. comments about relevance of the work to RLS or about role/activity in the IRLSSG meeting.) Applications should be sent by email to: IRLSSG Wayne Hening Award Committee c/o Allan O’Bryan Executive Secretary IRLSSG

2015 Wayne Hening Young Investigator Award Recipients: 

Laura Triguero: Prospective Study Of Iron Metabolism And Rls In Blood Donors
Aaro Salminen: Prepulse Inhibition And Auditory Startle Response In Meis1 Knock-out Mice

2014 Wayne Hening Young Investigator Award Recipients:

Suzie Bertisch: Cardiovagal Baroreflex Gain is Reduced in Patients with RLS
Thomas Dye: Long Term Treatment Outcomes of Iron Supplementation in Pediatric Restless Leg Syndrome and PLMD
Yong Seo Koo: Efficacy of Transcranial Direct Current Stimulation In Patients With Drug-Naïve Restless Legs Syndrome

2013 Wayne Hening Young Investigator Award Recipients:

Patrizia Congiu:  Neurophysiological evaluation of spinal excitability in patients affected by primitive restless legs syndrome
Amanda Freeman: PTPRD expression regulates sleep consolidation in drosophila
Samantha Kerr:  Reflex testing reveals circadian variation of spinal excitability in restless legs syndrome patients
Marta Moraleda-Cibrian: Restless leg syndrome in young children with orofacial cleft
Aaro Salminen:  Periodic leg movements in spinal cord injury: Evaluation of arousals and treatment effect
Andras Szentkiralyi: Multimorbidity and the risk of restless legs syndrome in two prospective cohort studies
Irina Zavalko: Polysomnographic evaluation of augmentation in patients with restless legs syndrome

2012 Wayne Hening Young Investigator Award Recipients:

Victoria Mery, McGill University, Montreal for High false-positive rate of questionnaire-based RLS diagnosis in MS
AQ Rana, PD Clinic and MD Center, Toronto for Exacerbation of Pain by RLS and PD, A Case Control Study.
Bryndis Benediktsdottiri, Landspitali University Hospital, Iceland for Prevalence of RLS among patients with OSA before and after CPAP treatment compared to the general population
Maryann Deak, Sleep Health Centers, Harvard Medical School, Boston for Correlates of respiratory events with and without associated leg movements in obstructive sleep apnea
Mark Boulos, University of Toronto for Nocturnal Limb Movements are Correlated with Cerebral White Matter Hyperintensities and Fronto-Executive Deficits