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Annual Meeting

IRLSSG 2025 Annual Meeting

June 8, 2025 | Seattle, WA USA

Attendance is open to all sleep professionals.

Registration is free for IRLSSG members and non-members attending the meeting for the first time. For non-member repeat attendees, registration is $100.

Why Attend?

This international meeting is devoted entirely and exclusively to Restless Legs Syndrome and other sleep-related movement disorders.
Expand your knowledge with the most recent advances in research, unpublished data and have a first-hand opportunity to discuss the topics with the authors.
Engage in pro-con debates and discussion groups
Present your ideas, your research results and receive feedback
Network with your colleagues. Meet old friends and consolidate new friendships.
Become an active participant in the IRLSSG community and help shape the future of RLS research.

Program Committee

Ambra Stefani (Austria)

Elias Karroum (USA)

Denise Sharon (USA)

Cornelius Bachmann (Germany)

John W. Winkelman (USA)

Lourdes Del Rosso (USA)

Rosalia Silvestri (Italy)

Location

Armory Loft 2 at Seattle Center

305 Harrison St

Seattle, WA 98109

Scientific Schedule

07:00 - 07:30

Breakfast

07:30 - 07:35

Welcome

John W. Winkelman (USA)

07:35 - 08:05

Business Meeting

08:05 - 10:05

Year in Review

Moderators: Rosalia Silvestri (Italy) & Elias G. Karroum (USA)

Structure:

Presentation - 12 Minutes

Discussion & Questions - 3 Minutes

1. Pediatric and Adult LMM (And Clinical Implications Including RSD)

Gulcin Benbir Senel (Turkey): "Pediatric LMM and RSD"

Ambra Stefani (Austria): "Adult LMM: Insights into Clinical Implications"

2. Pathophysiology of RLS

Sergi Ferre (USA): "Shared Neuronal Mechanisms of RLS and the Restlessness of Opioid Withdrawal"

3. Omics Science in RLS

Maria Mogavero (Italy): "Omics Insights and Future Direction in RLS"

Katie Cederberg (USA): "Proteomic Updates and Metabolomic Insights in RLS and PLMs"

4. RLS Genetics - Insights and Inspirations from a Large GWAS Meta-Analysis

Barbara Schormair (Germany): "Insights and Inspirations from a Large GWAS Meta-Analysis"

Fulya Akcimen (USA): "Genomic Insights into RLS in Diverse Genetic Ancestries: Multi-Ancestry GWAS Across Latin American, African, and Mixed Ancestries"

10:05 - 10:35

IRLSSG 30 Years Anniversary, 1995 - 2025

Arthur Walters (USA)

10:35 - 10:50

Coffee Break

10:50 - 11:50

Pro & Con Sessions

Moderators: Raffaele Ferri (Italy) & Christopher Earley (USA)

Structure:

Pro Argument - 10 Minutes

Con Argument - 10 Minutes

Discussion - 10 Minutes

1. Optimizing Augmentation Treatment

Rosalia Silvestri (Italy): "When to Consider Alpha-Delta Drugs and the Role of Iron & Vitamin D3 Supplementation"

Brian Koo (USA): "The Judicious Use of Opioids to Facilitate Tapering of Dopamine Agonists"

2. When Should We Use Dopaminergic Agents for RLS?

Michael Silber (USA) & Diego Garcia-Borreguero (Spain)

11:50 - 12:40

Clinical Case Presentations

Moderator: Denise Sharon (USA)

1. Augmentation of Restless Legs Syndrome Associated With Methadone

Christina A.H. Dirks (Germany)

2. Twist and Turns in the Night (and Day): Challenging Case of Augmented RLS Requiring Multiple Treatment Strategies

Joseph Russo (USA)

3. Real-World Outcomes of Patients Treated with TOMAC for Refractory RLS

Andrew Spector & Richard Bogan (USA)

12:40 - 13:00

Tonic Motor Activation (TOMAC) Therapy for Refractory RLS: Summary of Clinical Evidence

Mark Buchfuhrer

13:00 - 14:00

Lunch